AL 082D06游离态
AL 082D06游离态 性质
| 沸点 | 543.7±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.232±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO:6.25(最大浓度 mg/mL);15.25(最大浓度 mM) DMF:10.0(最大浓度 mg/mL);24.4(最大浓度 mM) DMF:PBS ( pH 7.2) (1:2):0.33(最大浓度 mg/mL);0.81(最大浓度 mM) |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 5.36±0.24(Predicted) |
AL 082D06游离态 用途与合成方法
| Target | Value |
|
Glucocorticoid receptor
() | 210 nM(Ki) |
AL 082D06 (D06) binds specifically to GR with nanomolar affinity. Addition of AL 082D06 causes a dose-dependent decrease in transcriptional activation from the MMTV:Luc reporter stimulated with half-maximal DEX concentrations. AL 082D06 acts to antagonize reporter activity using several glucocorticoid-responsive promoter- reporter systems including the 3-kb tyrosine amino transferase (TAT) promoter and less complex promoters comprised of isolated glucocorticoid response element (GRE) sequences. AL 082D06 competes with 3 H-Dex for baculovirus-expressed GR with nanomolar affinity. Other intracellular receptors (AR, ER, PR, and MR) have no affinity for AL 082D06 in a similarly structured binding assay with the appropriate receptor and tritiated ligand (>2500 nM). AL 082D06 has no activation efficacy on the progesterone, androgen, mineralocorticoid, retinoid, glucocorticoid, or estrogen receptors. AL 082D06 is very efficacious at antagonizing GR activity but exhibits much weaker efficacy when tested against the other steroid receptors in contrast to the reference antagonists used as controls.
AL 082D06游离态 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-15709 | AL 082D06游离态 | 256925-03-8 | 2mg | 2000 |
| 2024-01-25 | HY-15709 | AL 082D06游离态 | 256925-03-8 | 10mM * 1mLin DMSO | 2705 |
