eNOS catalyzes the formation of NO from L-arginine in many cell types including vascular endothelium, bronchiolar epithelium, cardiac myocytes, spleen, and kidney.1,2,3 Although eNOS was initially characterized as a constitutive enzyme, expression of eNOS mRNA is altered by many factors including shear stress, fibroblast growth factor, hypoxia, and LPS.4,5,6 eNOS is myristoylated and palmitoylated at the N-terminus, modifications which are required for localization to the plasmalalemmal caveolae of endothelial cells.7,8,9,10,11 Additionally, eNOS is phosphorylated on Ser1179 by protein kinase Akt resulting in an increase in NOS activity.12,13,14WARNING This product is not for human or veterinary use.
