Stimulator of Interferon Genes (STING) is a component of the innate immune response. STING binds to cyclic dinucleotides, which are bacterial second messengers.1 Recognition of cyclic-di-GMP (c-di-GMP), c-di-AMP, or c-GMP-AMP leads to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).2,3,4 Loss of STING regulation contributes to autoimmune disorders through increased IFN activity.5 The gene for STING is mutated in the mouse strain Goldenticket, which consequently lacks a type I IFN response to Listeria infection.6 Activation of STING by the flavonoid 5,6-dimethylxanthenone-4-acetic acid (DMXAA; Item No. 14617) has been shown to kill solid tumors in mice, but the binding site of DMXAA is not conserved in human STING.7,8WARNING This product is not for human or veterinary use.
