SP 141

$49 - $2995

Product nameSP 141
Cas No1253491-42-7
MFC22H16N2O
MW324.38
MDL NumberMFCD29059920

Synonyms

SP 141;6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 6-methoxy-1-(1-naphthalenyl)-;SP 141;SP141;;6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole;6-Methoxy-1-(1-naphthyl)-9H-β-carboline;pancreatic,SP-141,inhibit,Inhibitor,cancer,MDM-2/p53,breast,degradation,auto-ubiquitination,SP141;SP-141, 10 mM in DMSO

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Price

46 prices

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Cayman Chemical aablocks TRC Arctom ChemScene ApexBio Technology Axon Medchem AK Scientific ACHEMBLOCK Tocris Biosynth Usbiological DC Chemicals
Package less more

10mg 25mg 50mg 1mg 5mg 50 10 10mm*1mlindmso(solid+solvent) 100mg 250mg 1g 10mm*1mlindmso(solution)

Clear All Done

Brand	Packaging	Price	Product name
aablocks AA01E0KK	1mg	$49	Sp 141
aablocks AA01E0KK	5mg	$88	Sp 141
aablocks AA01E0KK	10mg	$124	Sp 141
aablocks AA01E0KK	25mg	$231	Sp 141
aablocks AA01E0KK	50mg	$247	Sp 141
aablocks AA01E0KK	100mg	$250	Sp 141
aablocks AA01E0KK	250mg	$452	Sp 141
aablocks AA01E0KK	1g	$1342	Sp 141
ACHEMBLOCK U109991	1G	$1035	SP141
ACHEMBLOCK U109991	100MG	$205	SP141

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Properties

Boiling point	571.2±45.0 °C(Predicted)
Density	1.284±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≤100mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form	crystalline solid
pka	15.04±0.40(Predicted)
color	White to yellow
InChI	1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3
InChIKey	AABFWJDLCCDJJN-UHFFFAOYSA-N
SMILES	COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Mouse double minute 2 protein (Mdm2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP 141 is a cell-permeable inhibitor of Mdm2 (Ki = 28 nM). Binding of Mdm2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation. SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo. This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

$38.00

SP-141

CAS:1253491-42-7
Career Henan Chemica Co
InvivoChem
Aladdin Scientific
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Shanghai Changyan Chem & Tech Co., Ltd.
Tianjin Kailiqi Biotechnology Co., Ltd.
ShangHai Biochempartner Co.,Ltd

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