Nsc736738;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Olomoucine II - CAS 500735-47-7 - Calbiochem;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-;Olomoucine II, CDK/cyclin inhibitor
Olomoucine II is a selective inhibitor of Cdk1(CDK1)/cyclin B (IC50 = 20 nM). Olomoucine II is a potent cytotoxin in tumor cells: IC50 = 5.3 μM against MCF7 cells, IC50 = 11.1 μM against K562 cells, IC50 = 3.0 μM against CEM cells, IC50 = 6.3 μM against HOS cells, and IC50 = 6.3 μM against G361 cells.
