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L-685 458
L-685 458
$87 - $2600
Product name
L-685 458
Cas No
292632-98-5
MF
C39H52N4O6
MW
672.85
MDL Number
MFCD03093402
Synonyms
(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide;N-[(2R,4R,5S)-5-[[(1,1-DiMethylethoxy)carbonyl]aMino]-4-hydroxy-1-oxo-6- phenyl-2-(phenylMethyl)hexyl]-L-leucyl-L-phenylalaninaMide;CS-2367;L-685458 (L-685,458;L-685458;L 685458;L685458;L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-;Apoptosis,alzheimer’s disease,L 685458,inhibit,L685458,HES1,cancer,Inhibitor,Gamma secretase,γ-secretase,L-685458;L-685,458, gamma-secretase inhibitor
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Price
59 prices
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aablocks
Cayman Chemical
ApexBio Technology
Arctom
Biosynth
ChemScene
AK Scientific
TRC
ACHEMBLOCK
DC Chemicals
Ambeed
Sigma-Aldrich
Crysdot
Chem-Impex
Usbiological
American Custom Chemicals Corporation
CSNpharm
Medical Isotopes, Inc.
Package
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10mm*1mlindmso(solution)
0.025mg
0.05mg
10mm*1mlindmso(solid+solvent)
0.1mg
10mm(1mlindmso)
250ug
0.25mg
0.5mg
500ug
1mg
2mg
5mg
10mg
25mg
50mg
100mg
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Brand
Packaging
Price
Product name
aablocks
AA002XTK
1mg
$87
L-685458
aablocks
AA002XTK
5mg
$249
L-685458
aablocks
AA002XTK
10mg
$407
L-685458
aablocks
AA002XTK
25mg
$767
L-685458
aablocks
AA002XTK
50mg
$1036
L-685458
aablocks
AA002XTK
100mg
$1372
L-685458
ACHEMBLOCK
U102942
25MG
$1120
L-685458
ACHEMBLOCK
U102942
100MG
$2025
L-685458
ACHEMBLOCK
U102942
5MG
$445
L-685458
AK Scientific
1682CP
10mg
$232
l-685,458
1
of
6
Properties
Melting point
212-213 °C
Boiling point
938.5±65.0 °C(Predicted)
Density
1.155±0.06 g/cm3(Predicted)
storage temp.
-20°C
solubility
DMSO: >10 mg/mL, soluble
form
solid
pka
12.09±0.46(Predicted)
color
white
InChIKey
MURCDOXDAHPNRQ-ZJKZPDEISA-N
SMILES
C(N)(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)C[C@@H](O)[C@@H](NC(OC(C)(C)C)=O)CC1=CC=CC=C1
Description
L-685,458 is a potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. It exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides.
Related product price
tert-butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanyl-OH
$38-2061
Z-ILE-PHE-OH
$128.33-1355
Suppliers and manufacturers
Shanghai fuxiang biotechnology co., ltd
J & K SCIENTIFIC LTD.
3B Pharmachem (Wuhan) International Co.,Ltd.
Chembest Research Laboratories Limited
Shanghai Hanhong Scientific Co.,Ltd.
Chemsky(shanghai)International Co.,Ltd.
Dalian Meilun Biotech Co., Ltd.
Haoyuan Chemexpress Co., Ltd.
MedChemexpress LLC
Nanjing Dulai Biotechnology Co., Ltd.
More related product prices
tert-butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanyl-OH
Z-ILE-PHE-OH
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