IKD-8344

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.^1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC₅₀ = 0.54 ng/ml).¹ IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.^2,3 It is active against T. spiralis in vitro and in vivo.¹