Doramapimod

$7 - $2200

Product nameDoramapimod
Cas No285983-48-4
MFC31H37N5O3
MW527.66
EINECS1308068-626-2
MDL NumberMFCD09752957

Synonyms

1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea;1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea;1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea;DoraMapiMod, BIBR-796;BIBR-796(DoraMapiMod);BIRB 796BS;N-[3-(1,1-DiMethylethyl)-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]urea;DoraMapin BIBR796

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Price

55 prices

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Sigma-Aldrich Cayman Chemical CSNpharm Arctom Chemenu Crysdot Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology Matrix Scientific AK Scientific Axon Medchem Medical Isotopes, Inc. ChemScene American Custom Chemicals Corporation Biosynth Carbosynth Ambeed DC Chemicals
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10mm(in1mldmso) 1unit 1mg 2mg 5mg 50 10mg 25mg 50mg 100mg 200mg 250mg 500mg 5g 10 1g

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Brand	Packaging	Price	Product name
AK Scientific X7401	25mg	$98	Doramapimod
Ambeed A103377	1g	$156	Doramapimod
Ambeed A103377	5mg	$7	Doramapimod
Ambeed A103377	10mg	$10	Doramapimod
Ambeed A103377	50mg	$25	Doramapimod
Ambeed A103377	100mg	$37	Doramapimod
Ambeed A103377	250mg	$66	Doramapimod
Ambeed A103377	5g	$537	Doramapimod
American Custom Chemicals Corporation KIN0000097	10MG	$750.75	DORAMAPIMOD
American Custom Chemicals Corporation KIN0000097	100MG	$1963.5	DORAMAPIMOD

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Properties

Melting point	142-143 °C
Boiling point	631.6±55.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
form	solid
pka	13.47±0.70(Predicted)
color	White or off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM. At 10 μM, doramapimod inhibits JNK2α2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.

Related product price

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Suppliers and manufacturers

career henan chemical co

$3.00/1KG

Doramapimod

CAS:285983-48-4
Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei Jusheng Technology Co.,Ltd.
Chongqing Chemdad Co., Ltd
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED
Hubei Ipure Biology Co., Ltd
Dideu Industries Group Limited

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