Dalbavancin is a second generation, semi-synthetic lipoglycopeptide antibiotic that is active against gram-positive pathogens with a MIC90for Staphylococcus aureus of 0.06 μg/mL. Dalbavancin possesses more potent in vitro bactericidal activity than vancomycin or teicoplanin against many resistant Gram-positive organisms such as MRSA. Dalbavanacin displays prolonged terminal half-life in adults.Compared to existing glycopeptides anti-MRSA(Methicillin-Resistant Staphylococcus Aureus) antibiotics, it has better antibiotic strength and, because it only needs to be taken once a week, it will be easier for both patients and medical care providers. It also offers stable absorption and metabolism for patients with light to moderate kidney and liver dysfunction. We know that its interactions with other medications are extremely small, and it is proving to be very safe in clinical trials.
Dalbavancin is specifically indicated for the treatment of adult patients with acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillinsusceptible and methicillin-resistant strains), Streptococcus pyogenes, Streptococcus agalactiae and Streptococcus anginosus group (including S. anginosus, S. intermedius, S. constellatus).
Class Glycopeptide anti-MRSA antibiotic
Mechanism of Action Cell Wall Peptidoglycan Synthesis Inhibitor
Target Indication MRSA Infections
