Thrombin Receptor Peptide Ligand (trifluoroacetate salt)

Thrombin receptor peptide ligand is antagonist of the thrombin receptor (EC50s = 16-33 µM to inhibit platelet aggregation in vitro).1 It inhibits α-thrombin and platelet aggregation induced by thrombin receptor activating peptide (TRAP; Item No. 24125) in vitro when used at a concentration of 32 µM but does not affect platelet aggregation induced by ADP or collagen. It also inhibits thrombin- and TRAP-induced proliferation of vascular smooth muscle cells (VSMCs).2 Thrombin receptor peptide ligand (100 µmol/kg bolus, i.v., plus 900 µmol/kg infusion) inhibits arterial thrombosis in a rabbit model of partial carotid artery occlusion without increasing bleeding time.3WARNING This product is not for human or veterinary use.