Peptide YY (human) (trifluoroacetate salt)

Peptide YY (PYY) is a 36-amino acid peptide and anorectic gut hormone agonist for the neuropeptide Y receptors Y1, Y2, Y5, and Y6 with EC50 values of 0.7, 0.58, 1, and 0.8 nM, respectively, for supression of forskolin-induced cAMP accumulation.1,2 PYY is cleaved in vivo to PYY (3-36) (Item No. 16502). Release of PYY occurs postprandially in proportion to calorie intake from intestinal enteroendocrine L cells, indicating it may be a satiety signal.3 In humans, PYY inhibits food intake and gastrointestinal transit in both lean and obese subjects.WARNING This product is not for human or veterinary use.