BAM15

$32 - $2014

Product nameBAM15
Cas No210302-17-3
MFC16H10F2N6O
MW340.29
EINECS201-118-7
MDL NumberMFCD00373912

Synonyms

BAM15;N,N'-bis(2-fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine;[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine, N5,N6-bis(2-fluorophenyl)-;BAM15 >=98% (HPLC);BAM 15 (N5,N6-bis(2-Fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine);inhibit,BAM-15,Inhibitor,BAM 15,BAM15,Mitochondrial Metabolism;BAM 15, 10 mM in DMSO;BAM 15 pure powder

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Price

65 prices

Brand less more

Cayman Chemical AvaChem Arctom Crysdot ChemScene TRC Axon Medchem Sigma-Aldrich Tocris AK Scientific Ambeed TCI Chemical DC Chemicals American Custom Chemicals Corporation Biosynth
Package less more

50mg 500mg 1g 25mg 250mg 50 10 10mm*1mlindmso(solid+solvent) 5mg 10mg 1mg 100mg 10mm*1mlindmso(solution)

Clear All Done

Brand	Packaging	Price	Product name
AK Scientific 5649CC	5mg	$201	5-N,6-N-Bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
Ambeed A924230	5mg	$211	BAM15
Ambeed A924230	10mg	$369	BAM15
Ambeed A924230	25mg	$646	BAM15
American Custom Chemicals Corporation BRS0009220	5MG	$450.09	BAM-15
Arctom HY-110284	50mg	$380	BAM 15
Arctom HY-110284	100mg	$570	BAM 15
Arctom HY-110284	250mg	$950	BAM 15
Arctom HY-110284	500mg	$1283	BAM 15
Arctom HY-110284	25mg	$238	BAM 15

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Properties

Boiling point	421.7±55.0 °C(Predicted)
Density	1.548±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (35 mg/ml)
pka	-2.40±0.50(Predicted)
form	powder
color	white to beige
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI	InChI=1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)
InChIKey	OEGJBRZAJRPPHL-UHFFFAOYSA-N
SMILES	C12=NON=C1N=C(NC1=CC=CC=C1F)C(NC1=CC=CC=C1F)=N2

Safety Information

Symbol(GHS)

Signal word

Danger

Hazard statements

H302：Harmful if swallowed

H361：Suspected of damaging fertility or the unborn child

H372：Causes damage to organs through prolonged or repeated exposure

H410：Very toxic to aquatic life with long lasting effects

Precautionary statements

P201：Obtain special instructions before use.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331：IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P312：Call a POISON CENTER or doctor/physician if you feel unwell.

Description

Typical mitochondrial uncouplers are lipophilic weak acids that increase proton transport into the mitochondrial matrix through an ATP synthase-independent pathway, thereby uncoupling nutrient oxidation from ATP production. These chemicals are used to determine rate of cellular respiration and have antioxidant effects that protect from ischemia-reperfusion injury. Most proton transporter uncouplers, however, exhibit off-target activity that can lead to undesired effects, including plasma membrane depolarization, mitochondrial inhibition, and cytotoxicity. BAM15 is a mitochondrial protonophore uncoupler that does not depolarize the plasma membrane and protects mice from acute renal ischemic-reperfusion injury. In comparison to FCCP , 1-10 μM BAM15 was shown to increase oxygen flux with equal potency as the classic uncoupler, while displaying a higher maximum rate of mitochondrial respiration and less cytotoxicity.