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ChemicalBook CAS DataBase List Apremilast

Apremilast

$50 - $1208.7

Product nameApremilast
Cas No608141-41-9
MFC22H24N2O7S
MW460.5
EINECS807-237-6
MDL NumberMFCD18782607

Synonyms

(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide;ApreMilast,CC-10004;AcetaMide, N-[2-[(1S)-1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide Apremilast (CC-10004;(S)-N-(2-(1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl);Apremilast (S)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione;Appleton West;N-[2-[(1S)-1-(3ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide

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Price

48 prices

Brand less more

TCI Chemical Sigma-Aldrich Cayman Chemical AccelPharmtech TRC Biorbyt Ltd ApexBio Technology Matrix Scientific AK Scientific Axon Medchem Medical Isotopes, Inc. ChemScene Biosynth Carbosynth Labseeker DC Chemicals
Package less more

1unit 1mg 5mg 10mg 25mg 50mg 100mg 250mg 1000mg 10mm(in1mldmso) 1g 2.5g 5g 10g 25g

Clear All Done

Brand	Packaging	Price	Product name
AccelPharmtech XP2469	5G	$120	Apremilast
AccelPharmtech XP2469	25G	$260	Apremilast
AK Scientific Y0437	10mg	$108	Apremilast
ApexBio Technology A4317	25mg	$110	Apremilast (CC-10004)
ApexBio Technology A4317	5mg	$80	Apremilast(CC-10004)
ApexBio Technology A4317	10mg	$88	Apremilast (CC-10004)
ApexBio Technology A4317	5mg	$55	Apremilast (CC-10004)
ApexBio Technology A4317	10mM(in1mLDMSO)	$61	Apremilast (CC-10004)
ApexBio Technology A4317	10mg	$120	Apremilast(CC-10004)
ApexBio Technology A4317	50mg	$250	Apremilast(CC-10004)

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Properties

Melting point	152-156°C
Boiling point	741.3±60.0 °C(Predicted)
Density	1.381
storage temp.	Refrigerator
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka	14.01±0.20(Predicted)
form	Solid
color	White to Pale Yellow
InChI	1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
InChIKey	IMOZEMNVLZVGJZ-QGZVFWFLSA-N
SMILES	C(NC1=CC=CC2=C1C(=O)N([C@@H](C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O)C2=O)(=O)C
CAS DataBase Reference	608141-41-9

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H361：Suspected of damaging fertility or the unborn child

Precautionary statements

P201：Obtain special instructions before use.

P202：Do not handle until all safety precautions have been read and understood.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P281：Use personal protective equipment as required.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313：IF exposed or concerned: Get medical advice/attention.

P330：Rinse mouth.

P405：Store locked up.

P501：Dispose of contents/container to..…

Description

Apremilast (Otezla) was approved by the FDA on March 21, 2014 for the treatment of adult patients with active psoriatic arthritis. Apremilast is a member of a new class of oral small molecule inhibitors of the phosphosphodiesterase 4 (PDE4) enzyme. When PDE4 is inhibited in immune cells, it results in elevation of intracellular cyclic adenosine monophosphate (cAMP) levels, which can regulate inflammatory mediators. The current clinical data indicate that apremilast is an effective and well tolerated option for the management of psoriasis and PsA in adults.

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Suppliers and manufacturers

Jinan Jianfeng Chemical Co., Ltd

$0.00/1kg

Apremilast

CAS:608141-41-9
Hebei Chuanghai Biotechnology Co., Ltd

$10.00/1KG

ApreMilast

CAS:608141-41-9
shandong perfect biotechnology co.ltd

$0.00/1g

Apremilast

CAS:
Hangzhou ICH Biofarm Co., Ltd

$0.00/1kg

Apremilast

CAS:608141-41-9
Henan Fengda Chemical Co., Ltd

$1.00/100KG

Apremilast

CAS:608141-41-9
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

$750.00/ton

Apremilast

CAS:608141-41-9
Cangzhou Kangrui Pharma Tech Co. Ltd.,

$0.00/100g

Apremilast

CAS:608141-41-9
HAINAN POLY PHARMCEUTICAL CO. LTD
Beijing Mesochem Technology Co.,Ltd
Wuhan Topule Biopharmaceutical Co., Ltd

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