1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE;RHC-80267;U-57908;N,N'-[1,6-Hexanediylbis(iminocarbonyloxy)]bis(cyclohexanimine);1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane;1,6-bis(cyclohexyloximinocarbonyl)hexane;1,6-bis(Cyclohexyloximinocarbonylamino)hexane, U 57908;Cyclohexanone, o,o'-(1,6-hexanediylbis(iminocarbonyl))dioxime
P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
Diacylglycerol (DAG) is an important cellular source of arachidonic acid which may be released by the action of DAG lipase. RHC-80267 is a selective inhibitor of DAG lipase (IC50 = 4 μM in canine platelets) that demonstrates relatively weak inhibition of phospholipases A2 and C. By elevating the concentration of diacylglycerol, RHC-80267 is thought to initiate activation of protein kinase C. At 0.3-1 μM, it has been reported to enhance acetylcholine-induced smooth muscle relaxation in vitro.
