PRIMA-1MET(5291-32-7) reactivates mutant p53, an important tumor suppressor gene, in cancer cells.1It induces p53-dependent mitochondrial apoptosisviaactivation of caspase-2.2PRIMA-1METshowed significant antitumor activity in multiple myelomaviaactivation of p733and had previously been shown to target p53 family members p63 and p734. Tumor cell death by PRIMA-1METhas been also shown to be caused by glutathione depletion and induced ROS production in a p53 independent manner.5-7PRIMA-1METprobably induces tumor cell death by both reactivating mutant p53 and inhibiting cellular thiol-dependent redox systems.8
![2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one](https://www.chemicalbook.com/CAS/GIF/5291-32-7.gif)
