trans-2-Phenacyl-cyclohexanecarboxylic Acid is an intermediate in the synthesis of trans-1,2,3,4,4a,10,11,11a-Octahydro-N,N-dimethyl-5H-Dibenzo[a,d]cycloheptene-Δ5,γ-propylamine Hydrochloride (Amitriptyline EP Impurity E) (O236425), which is an impurity of Amitriptyline (A633350), which is an antidepressant.