1,8-Dimethyl-1,4,8,11-tetraazacyclotetradecane may be used as a precursor for the synthesis of `trans′-difunctionalized derivatives.It may also be used in the synthesis of 4,11-bis(N-pyren-1-yl-acetamide)-1,8-dimethyl-1,4,8,11-tetraazacyclotetradecane.