(1R,4R)-4-((2-Nitrophenyl)amino)cyclohexanol is used as a reactant in the discovery of EGF816, a novel, potent, and WT sparing covalent inhibitor of oncogenic (L858R, ex19del) and resistant (T790M) EGFR mutants for treatment of EGFR mutant non-small-cell lung cancers.
