6-МЕТИЛАМИНОПУРИН 9-РИБОФУРАНОЗИД
- английское имя6-METHYLAMINOPURINE 9-RIBOFURANOSIDE
- CAS №1867-73-8
- CBNumberCB9503892
- ФормулаC11H15N5O4
- мольный вес281.27
- EINECS200-001-2
- номер MDLMFCD00005739
- файл Mol1867-73-8.mol
химическое свойство
| Температура плавления | 172 °C |
| Температура кипения | 649.1±65.0 °C(Predicted) |
| плотность | 1.85±0.1 g/cm3(Predicted) |
| температура хранения | Keep in dark place,Sealed in dry,2-8°C |
| растворимость | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) |
| форма | Powder |
| пка | 13.12±0.70(Predicted) |
| цвет | White to off-white |
| РН | 4.0 |
| λмакс | 262 (pH 1)；266 (pH 7) |
| Стабильность | Hygroscopic |
| FDA UNII | CLE6G00625 |
6-МЕТИЛАМИНОПУРИН 9-РИБОФУРАНОЗИД химические свойства, назначение, производство
Описание
N6-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.Использование
N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.Определение
ChEBI: A methyladenosine compound with one methyl group attached to N6 of the adenine nucleobase.6-МЕТИЛАМИНОПУРИН 9-РИБОФУРАНОЗИД запасные части и сырье
6-МЕТИЛАМИНОПУРИН 9-РИБОФУРАНОЗИД поставщик
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