RO-3306
- английское имяRo 3306
- CAS №872573-93-8
- CBNumberCB92535693
- ФормулаC18H13N3OS2
- мольный вес351.45
- номер MDLMFCD17392573
- файл Mol872573-93-8.mol
химическое свойство
| Температура кипения | 569.1±60.0 °C(Predicted) |
| плотность | 1.41 |
| температура хранения | 2-8°C |
| растворимость | DMSO: soluble5mg/mL, clear |
| пка | 3.99±0.10(Predicted) |
| форма | powder |
| цвет | white to light brown |
| Стабильность | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
RO-3306 химические свойства, назначение, производство
Использование
RO-3306 is an ATP-competitive and selective CDK1 inhibitor used against a diverse panel of human kinases. Used in the treatment of malignant tumors in conjunction with PARP inhibitors.Биохимия/физиол Действия
RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.RO-3306 поставщик
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