Ресаторвид
- английское имяRESATORVID
- CAS №243984-11-4
- CBNumberCB92455670
- ФормулаC15H17ClFNO4S
- мольный вес361.82
- номер MDLMFCD11046362
- файл Mol243984-11-4.mol
химическое свойство
| Температура плавления | 68-69℃ |
| Температура кипения | 462.0±55.0 °C(Predicted) |
| плотность | 1.39 |
| температура хранения | Sealed in dry,Room Temperature |
| растворимость | insoluble in H2O; ≥100.6 mg/mL in EtOH; ≥18.09 mg/mL in DMSO |
| форма | Solid |
| пка | 7.08±0.40(Predicted) |
| цвет | Off-white to yellow |
| FDA UNII | H2MZ648C31 |
Ресаторвид химические свойства, назначение, производство
Общее описание
A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9 nM, respectively, against LPS-induced NO, IL-6, and TNF-α production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7 mg/kg, i.p.) induced death in mice (3 mg/kg; i.v.) in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 508336).Биохимия/физиол Действия
Cell permeable: yesРесаторвид поставщик
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