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Scutellarin
- русский язык имя
- английское имяScutellarin
- CAS №27740-01-8
- CBNumberCB9117918
- ФормулаC21H18O12
- мольный вес462.36
- EINECS1806241-263-5
- номер MDLMFCD01861503
- файл Mol27740-01-8.mol
химическое свойство
Температура плавления | 300~301℃ |
Температура кипения | 891.6±65.0 °C(Predicted) |
плотность | 1.810±0.06 g/cm3(Predicted) |
температура хранения | Sealed in dry,2-8°C |
растворимость | DMSO (Slightly), Methanol (Very Slightly, Sonicated) |
пка | 2.72±0.70(Predicted) |
форма | Solid |
цвет | Light Yellow to Yellow |
БРН | 71779 |
Справочник по базе данных CAS | 27740-01-8(CAS DataBase Reference) |
FDA UNII | 16IGP0ML9A |
Заявления о безопасности | 24/25 |
WGK Германия | 3 |
кода HS | 29389090 |
Scutellarin химические свойства, назначение, производство
Описание
Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties. It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 μM, effects that can be blocked by the autophagy inhibitor HCQ . Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg. It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.Определение
ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein.Scutellarin запасные части и сырье
сырьё
запасной предмет
Scutellarin поставщик
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