Ванадоцен дихлорид

Химические свойства

dark green crystalline powder

Использование

Vanadocene dichloride is used like other metallocenes as a catalyst, ultraviolet absorber, reducing agent, free radical scavenger, antiknock agent in gasoline, and as a developmental anticancer drug.

Общее описание

Pale green crystals or green powder.

Реакции воздуха и воды

Extremely sensitive to exposure to air. Also extremely sensitive to moisture; decomposes in water

Профиль реактивности

Organometallics, such as BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water.

Пожароопасность

Flash point data for BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE are not available. BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is probably combustible.

Фармацевтические приложения

Vanadocene dichloride [( η⁵-C₅H₅)₂VCl₂, dichloro bis(η⁵-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp₂TiCl₂. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic .
Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp₂TiCl₂ because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. The main problems are the difficult characterisation of the active vanadium compounds and their fast hydrolysis.