AG 1478
- русский язык имя
- английское имяAG 1478
- CAS №175178-82-2
- CBNumberCB8751920
- ФормулаC16H14ClN3O2
- мольный вес315.75
- номер MDLMFCD00270914
- файл Mol175178-82-2.mol
химическое свойство
| Температура плавления | 180 - 183°C |
| температура хранения | 2-8°C |
| растворимость | 0.1 M HCl: soluble <0.4 mg/mL |
| форма | Pale yellow solid |
| цвет | Off-white |
| Стабильность | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | TC62B68RSL |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
AG 1478 химические свойства, назначение, производство
Использование
Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.Общее описание
Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 >100 μM), the platelet-derived growth factor (PDGF) receptor (IC50 >100 μM), and p210Bcr-Abl (IC50 >50 μM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.Биохимия/физиол Действия
Primary TargetEpidermal growth factor receptor kinaseAG 1478 поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
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