Pterostilbene
- русский язык имя
- английское имяPterostilbene
- CAS №537-42-8
- CBNumberCB8373368
- ФормулаC16H16O3
- мольный вес256.3
- EINECS611-041-4
- номер MDLMFCD00238710
- файл Mol537-42-8.mol
химическое свойство
| Температура плавления | 89-92 ºC |
| Температура кипения | 420.4±35.0 °C(Predicted) |
| плотность | 1.169±0.06 g/cm3(Predicted) |
| температура хранения | 2-8°C |
| растворимость | DMSO: >20mg/mL |
| пка | 9.96±0.26(Predicted) |
| форма | solid |
| цвет | White or off-white |
| Запах | Characteristic |
| λмакс | 321nm(MeOH)(lit.) |
| Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
| InChI | InChI=1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+ |
| ИнЧИКей | VLEUZFDZJKSGMX-ONEGZZNKSA-N |
| SMILES | C1(O)=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1 |
| LogP | 4.056 (est) |
| Рейтинг продуктов питания EWG | 1 |
| FDA UNII | 26R60S6A5I |
| Словарь наркотиков NCI | pterostilbene |
| Коды опасности | Xi,N | |||||||||
| Заявления о рисках | 41-51/53 | |||||||||
| Заявления о безопасности | 26-39-61 | |||||||||
| РИДАДР | 3077 | |||||||||
| WGK Германия | 3 | |||||||||
| Класс опасности | IRRITANT | |||||||||
| Группа упаковки | Ⅲ | |||||||||
| кода HS | 29095000 | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H318：При попадании в глаза вызывает необратимые последствия.
H411：Токсично для водных организмов с долгосрочными последствиями.
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оператор предупредительных мер
P273：Избегать попадания в окружающую среду.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P391：Ликвидировать просыпания/проливы/утечки.
P501：Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Pterostilbene химические свойства, назначение, производство
Описание
Pterostilbene (PTS) is a fragrant-smelling hydrocarbon called "styrene", which is a derivative of resveratrol. It is found in blueberries and Pterocarpus marsupium (PM) heartwood. Similar to resveratrol, PTS has anti-inflammatory, anti-thrombotic, anti-cancer, anti-cancer, anti-hyperlipidemia and antibacterial effects.Химические свойства
Pterostilbene is a white crystalline powder, sensitive to air, soluble in hot methanol, DMSO, insoluble in water. It is a stilbenoid chemically similar to resveratrol and from the leguminous plant Pterocarpus indicus.Вхождение
Pterostilbene is a natural molecule found in fruits, vegetables and nuts. Blueberries are often quoted as one of the richest sources of pterostilbene. It is also found in almonds,various Vaccinium berries (including blueberries), grape leaves and vines,and Pterocarpus marsupium heartwood.Использование
Substantial studies demonstrate that pterostilbene has diverse pharmacological activities for the prevention and treatment of diseases including inflammation, cancer, diabetes, and dyslipidemia.Pterostilbene has been used:
to investigate its anti-oxidative stress activities and the involvement of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) signaling pathway
to determine its effects on transcriptional activation of estrogen receptor-α (ERα) in hormone resistant breast cancer cells)
Подготовка
Pterostilbene was synthesized from 3,5-dimethoxybenzyl bromide and p-nitrobenzaldehyde by Witting-Hornor reaction, reduction, diazotization and hydrolysis, with a total yield of 53.9%.
Определение
ChEBI: Pterostilbene is a stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'. It has a role as an antioxidant, an antineoplastic agent, a neurotransmitter, a plant metabolite, an apoptosis inducer, a neuroprotective agent, an anti-inflammatory agent, a radical scavenger and a hypoglycemic agent. It is a stilbenol, a member of methoxybenzenes and a diether. It derives from a hydride of a trans-stilbene.преимущество
Pterostilbene is a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Pterostilbene is known to have many pharmacological benefits for the prevention and treatment of a wide variety of diseases, including ( cancer (McCormack and McFadden 2012), dyslipidaemia (Rimando et al. 2005), diabetes (Amarnath Satheesh and Pari 2006), cardiovascular degeneration (Amarnath Satheesh and Pari 2008) and pain (Hougee et al. 2005).Побочные эффекты
The side effects of pterostilbene are relatively minor, but you still need to pay attention to the dosage. Low-dose pterostilbene supplementation improves cholesterol metabolism and reduces triglyceride levels. Side effects include mild weight loss and muscle pain, but dose adjustment is usually not necessary.Pterostilbene запасные части и сырье
Pterostilbene поставщик
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