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![D-амигдалин структурированное изображение](/CAS/GIF/29883-15-6.gif)
D-амигдалин
- английское имяAmygdalin
- CAS №29883-15-6
- CBNumberCB8363552
- ФормулаC20H27NO11
- мольный вес457.43
- EINECS249-925-3
- номер MDLMFCD00006598
- файл Mol29883-15-6.mol
химическое свойство
Температура плавления | 223-226 °C |
альфа | -38.5 º (c=4, H2O) |
Температура кипения | 563.27°C (rough estimate) |
плотность | 1.4474 (rough estimate) |
показатель преломления | -40 ° (C=2, H2O) |
температура хранения | Sealed in dry,Room Temperature |
растворимость | H2O: 0.1 g/mL hot, clear to very faintly turbid, colorless |
форма | Powder |
пка | 12.69±0.70(Predicted) |
цвет | White to Off-white |
оптическая активность | [α]20/D 39±2°, c = 2% in H2O |
Растворимость в воде | 83 g/L (25 ºC) |
Мерк | 14,597 |
БРН | 66856 |
Стабильность | Hygroscopic |
ИнЧИКей | XUCIJNAGGSZNQT-SWRVSKMJSA-N |
LogP | -2.237 (est) |
Справочник по базе данных CAS | 29883-15-6(CAS DataBase Reference) |
Рейтинг продуктов питания EWG | 1 |
Словарь онкологических терминов NCI | amygdalin; laetrile |
FDA UNII | 214UUQ9N0H |
Словарь наркотиков NCI | laetrile |
больше
Коды опасности | Xn | |||||||||
Заявления о рисках | 22 | |||||||||
Заявления о безопасности | 26-36/37/39-45-24/25 | |||||||||
РИДАДР | 2811 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | OO8450000 | |||||||||
F | 10-21 | |||||||||
Класс опасности | 6.1(b) | |||||||||
Группа упаковки | III | |||||||||
кода HS | 29389090 | |||||||||
Банк данных об опасных веществах | 29883-15-6(Hazardous Substances Data) | |||||||||
Токсичность | LD50 orl-rat: 522 mg/kg WJMDA2 134,97,81 | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H302:Вредно при проглатывании.
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оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P270:При использовании продукции не курить, не пить, не принимать пищу.
P301+P312:ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
D-амигдалин химические свойства, назначение, производство
Описание
Amygdalin is a cyanogenic glycoside that has been found in seeds from plants of the Rosaceae family and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase, decreases cyclin A and Cdk2 levels, and inhibits cell growth in UMUC-3, RT112, and TCCSUP bladder cancer cells when used at concentrations ranging from 1.25 to 10 mg/ml. Amygdalin (3 mg/kg) reduces the number of primary microtubules and microvessels in aortic rings isolated from rats with diabetes induced by streptozotocin . In vivo, amygdalin reduces triglyceride, total cholesterol, and LDL levels and aortic sinus plaque area in an LDLR-/- mouse model of atherosclerosis. It also reduces production of TNF-α, IL-1β, and IL-6, as well as neutrophil and macrophage infiltration, in bronchoalveolar lavage fluid (BALF) in a mouse model of LPS-induced acute lung injury.Химические свойства
WHITE FINE CRYSTALLINE POWDERИспользование
Amygdalin, a cyanide containing glycoside, may be used as a substrate to identify, differentiate and characterize enzymes such as maltase(s), emulsin(s) and β-glucosidase(s).Определение
ChEBI: An amygdalin in which the stereocentre on the cyanohydrin function has R-configuration.Всемирная организация здравоохранения(ВОЗ)
Laetrile, which consists mainly of amydgalin, a glycoside extracted from the kernels of apricots, peaches and other fruits, has been available for over 30 years in preparations purporting to be beneficial in the treatment of cancer. Although there is no evidence that these are efficacious, preparations continued to be widely used and, until the late 1970s, they were considered to be harmless. However, oral dosage forms, which may be broken down in the gut to hydrogen cyanide, have subsequently been shown to be potentially lethal. This has resulted in restrictive regulatory measures in several countries.Общее описание
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KGПрофиль безопасности
Human poison by ingestion(infant data). Poison experimentally by ingestion. Anexperimental teratogen. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.Методы очистки
D-Amygdalin recrystallises from water as the trihydrate, or from EtOH. It is present in bitter almonds. [Smith Chem Ber 64 1115 1931, Beilstein 17/8 V 188.]D-амигдалин запасные части и сырье
запасной предмет
D-амигдалин поставщик
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