GZD 824
- русский язык имя
- английское имяGZD 824
- CAS №1257628-77-5
- CBNumberCB82666626
- ФормулаC29H27F3N6O
- мольный вес532.56
- номер MDLMFCD26142930
- файл Mol1257628-77-5.mol
химическое свойство
| Температура кипения | 630.4±55.0 °C(Predicted) |
| плотность | 1.39±0.1 g/cm3(Predicted) |
| температура хранения | Store at -20°C |
| растворимость | DMSO : ≥ 100 mg/mL (187.77 mM) |
| форма | A crystalline solid |
| пка | 9.04±0.40(Predicted) |
| цвет | Off-white to yellow |
| FDA UNII | KV1M7Q3CBP |
GZD 824 химические свойства, назначение, производство
Описание
GZD-824 is an orally available inhibitor of a broad spectrum of Bcr/Abl tyrosine kinase mutants including T315I (IC50s = 0.34 and 0.68 nM for wild-type Bcr/Abl and Bcr/AblT315I, respectively). It has been shown to suppress the proliferation of Bcr/Abl-positive K562 and Ku812 human chronic myelogenous leukemia cells (IC50s = 0.2 and 0.13 nM, respectively) and induce tumor regression in mouse xenograft tumor models driven by either wild-type or mutant Bcr/Abl.Использование
GZD824 is a orally bioavailable inhibitor that targets phosphorylated and non-phosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) kinases. It is a COVID19-related research product.target
BCR-ABLGZD 824 запасные части и сырье
GZD 824 поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
| 025-83697070 | CHINA | 3012 | 60 | |
| +undefined-21-51877795 | China | 32836 | 60 | |
| +86-755-23284190 13684996853 | CHINA | 304 | 58 | |
| 18871490254 | CHINA | 28180 | 58 | |
| +86-0371-86658258 +8613203830695 |
China | 30250 | 58 | |
| 86-571-88216897,88216896 13588875226 |
CHINA | 6313 | 58 | |
| +86-29-89586680 +86-15129568250 |
China | 23499 | 58 | |
| +8615056975894 | CHINA | 9923 | 58 | |
| +1-708-310-1919 +1-13798911105 |
United States | 6393 | 58 | |
| +86-571-86626709 +86-18157142896 |
China | 9991 | 58 |