L-Ribose

Химические свойства

white crystals or powder

Использование

L-[1-13C]ribose is a compound useful in organic synthesis.

Определение

ribose: A monosaccharide, C₅H₁₀O₅, rarely occurring free in nature but important as a component of RNA (ribonucleic acid). Its derivative deoxyribose, C₅H₁₀O₄, is equally important as a constituent of DNA (deoxyribonucleic acid), which carries the genetic code in chromosomes.

Биосинтез

L-ribose is the enantiomer of D-ribose, which occurs naturally. It is a building block of many novel nucleotide analogue anti-viral drugs. Bio-production of L-ribose relies on a two-step reaction: (i) conversion of L-arabinose to L-ribulose by the catalytic action of L-arabinose isomerase (L-AI) and (ii) conversion of L-ribulose to L-ribose by the catalytic action of L-ribose isomerase (L-RI, EC 5.3.1.B3) or mannose-6-phosphate isomerase (MPI, EC 5.3.1.8, alternately named as phosphomannose isomerase). Among the two enzymes, L-RI is a rare enzyme discovered in 1996 by Professor Izumori's group, whereas MPI is an essential enzyme in metabolic pathways in humans and microorganisms[1].