![ChemicalBook](https://m.chemicalbook.com/Scripts/New/img/logo.png)
![структурированное изображение](/CAS/20180808/GIF/496775-62-3.gif)
Eltrombopag Olamine
- русский язык имя
- английское имяEltrombopag Olamine
- CAS №496775-62-3
- CBNumberCB82495099
- ФормулаC27H29N5O5
- мольный вес503.56
- EINECS629-876-8
- номер MDLMFCD22380664
- файл Mol496775-62-3.mol
химическое свойство
температура хранения | under inert gas (nitrogen or Argon) at 2–8 °C |
растворимость | DMSO:56.33(Max Conc. mg/mL);99.76(Max Conc. mM) DMF:1.0(Max Conc. mg/mL);1.77(Max Conc. mM) DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.44(Max Conc. mM) Ethanol:0.1(Max Conc. mg/mL);0.18(Max Conc. mM) |
форма | Powder |
Стабильность | Hygroscopic |
ИнЧИКей | LQQUHOUXABUDJA-OUFJFOJPSA-N |
SMILES | C(N)CO.O=C1/C(/C(C)=NN1C1C=CC(C)=C(C)C=1)=N\NC1C=CC=C(C2C=CC=C(C(=O)O)C=2)C=1O |
Словарь онкологических терминов NCI | eltrombopag olamine |
FDA UNII | 4U07F515LG |
Словарь наркотиков NCI | eltrombopag olamine |
рисовальное письмо(GHS)
-
рисовальное письмо(GHS)
-
сигнальный язык
предупреждение
-
вредная бумага
H319:При попадании в глаза вызывает выраженное раздражение.
H412:Вредно для водных организмов с долгосрочными последствиями.
-
оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P273:Избегать попадания в окружающую среду.
P280:Использовать перчатки/ средства защиты глаз/ лица.
P305+P351+P338:ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Eltrombopag Olamine химические свойства, назначение, производство
Описание
Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough.Eltrombopag has also been recently approved (late 2012) for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy.Использование
Treatment of chemotherapy-induced thrombocytopenia and treatment of immune thrombocytopenic purpura.Клиническое использование
Eltrombopag olamine, a thrombopoietin receptor (TpoR) agonist, was approved in late 2008 for the once-daily, oral short-term and long-term treatment of adult patients with previously treated chronic idiopathic thrombocytopenic purpura (ITP). It is the first small-molecule TpoR agonist and was launched in the U.S. for this indication in 2009 by GlaxoSmithKline (GSK). Because eltrombopag is a small molecule, the drug is administered orally and has a reduced potential for causing an immune system reaction versus alternative protein-based therapies. In 2010, eltrombopag was approved in Europe for the long-term treatment of adult patients with previously treated chronic ITP.Синтез
The synthesis began with the nitration of 2-bromophenol (39) with sodium nitrate and sulfuric acid in water at 10??C to give 2-bromo-6-nitrophenol (40) in 25% yield, which was methylated using methyl iodide and potassium carbonate in refluxing acetone providing 2-bromo- 6-nitroanisole (41) in 76% yield (the Scheme).40 Suzuki coupling of compound 41 with 3-carboxyphenyl boronic acid with Pd(PPh3)4 and 2 M sodium carbonate in refluxing dioxane gave 20-methoxy- 30-nitrobiphenyl-3-carboxylic acid (42) in 47% yield as a tan powder. Demethylation using 48% HBr (aq) in refluxing acetic acid resulted in a 79% yield of 20-hydroxy-30-nitrobiphenyl-3-carboxylic acid (43). The nitro group of compound 43 was reduced via catalytic hydrogenation at 50 psi at room temperature over Pd/C in mixed ethanol/3 M aq NaOH solution to give 30-amino-20-hydroxybiphenyl- 3-carboxylic acid (44) in quantitative yield. The intermediate 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1Hpyrazol- 5-one (47) was prepared by condensing of 3,4-dimethylphenyl- hydrazine 45 with ethyl acetoacetate 46 with sodium acetate in refluxing acetic acid in 76% yield. Treatment of (44) with sodium nitrite in 1 M HCl at 5??C, followed by condensation with 1-(3,4-dimethylphenyl)-3-methyl-2,5-dihydro-1H-pyrazol-5-one (47) at a constant pH of 7¨C8 via the addition of sodium bicarbonate and ethanol afforded eltrombopag in 32% yield. Finally, eltrombopag was treated with hydroxyl ethylamine to give eltrombopag olamine (VIII).Eltrombopag Olamine поставщик
поставщик | телефон | страна | номенклатура продукции | благоприятные условия | |
---|---|---|---|---|---|
+86-18600796368 +86-18600796368 |
China | 143 | 58 | ||
+8613651027935 | China | 191 | 58 | ||
+86-15552509998 +86-15621883869 |
China | 251 | 58 | ||
+86-0533-2185556 +8617865335152 |
China | 10991 | 58 | ||
+86-0311-67591193 +8613931880626 |
China | 251 | 58 | ||
+86-17332992504 +86-17332992504 |
China | 300 | 58 | ||
571-85586718 +8613336195806 |
China | 29798 | 60 | ||
+86-21-33585366 - 03@ | CHINA | 738 | 60 | ||
+undefined-21-51877795 | China | 32836 | 60 | ||
+86-0371-86658258 +8613203830695 |
China | 29889 | 58 |