Хинупристин
- английское имяQuinupristin
- CAS №120138-50-3
- CBNumberCB81073487
- ФормулаC53H67N9O10S
- мольный вес1022.23
- номер MDLMFCD00865105
- файл Mol120138-50-3.mol
химическое свойство
Температура плавления | ~200° |
форма | Solid |
цвет | White to off-white |
FDA UNII | 91VAC8654E |
Банк данных об опасных веществах | 120138-50-3(Hazardous Substances Data) |
Хинупристин химические свойства, назначение, производство
Описание
Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria. Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin , to produce quinupristin-dalfopristin complex , known commercially as Synercid. While both quinupristin and dalfopristin have bacteriostatic effects, they act synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria.Использование
Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.Хинупристин поставщик
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