1-амино-1-циклопентанкарбоновая кислота

Химические свойства

WHITE TO BEIGE CRYSTALLINE FLAKES OR POWDER

Использование

Cycloleucine is a synthetic amino acid used in numerous biochemical transport studies

Определение

ChEBI: A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups.

Общее описание

Cycloleucine is a nonmetabolizable amino acid widely used as a building block in peptide synthesis.

Методы очистки

Any Cl -or other anions are removed by stirring with a strong cation exchange resin (Amberlite IR-120), filtering, and washing with distilled H2O until the filtrate is free from the anion. The resin is then stirred overnight with 6N NH4OH, filtered, the filtrate is decolourised (charcoal) and evaporated to dryness in a vacuum. The residue is recrystallised from H2O/EtOH. Also crystallise it from aqueous EtOH. The hydrochloride has m 222-224o(dec). [Neelakantan & Hartung J Org Chem 23 967 1958, Connors & Ross J Chem Soc 2119 1960. O’Donnell et al. Synthesis 127 1984, Beilstein 14 IV 974.]