7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- русский язык имя
- английское имя7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
- CAS №73942-87-7
- CBNumberCB71503994
- ФормулаC12H13NO3
- мольный вес219.24
- EINECS456-160-0
- номер MDLMFCD02091565
- файл Mol73942-87-7.mol
химическое свойство
| Температура плавления | 244.0 to 248.0 °C |
| Температура кипения | 455.8±45.0 °C(Predicted) |
| плотность | 1.167 |
| температура хранения | Sealed in dry,Room Temperature |
| растворимость | Chloroform (Slightly), DMSO (Slightly) |
| форма | Solid |
| пка | 13.29±0.20(Predicted) |
| цвет | Off-White to Pale Beige |
| LogP | 1.23 at 23℃ and pH6.47 |
| Surface tension | 71mN/m at 36.9mg/L and 19℃ |
| Справочник по базе данных CAS | 73942-87-7(CAS DataBase Reference) |
| FDA UNII | HV3ZHP3F8A |
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one химические свойства, назначение, производство
Использование
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is a substituted benzazepinonee derivative used in the preparation of bradycardic agents as well as isoform-selective f-current blockers.прикладной
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one is used in the industrial preparation of pharmaceuticals and can be reacted with trifluoroacetic acid to form 3,4-dimethoxyphenylacetic acid.Синтез
1.Charge 142.0 g of N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl) acetamide, 710 ml of glacial acetic acid and 710 ml of conc. hydrochloric acid in a 3.0 L round bottom flask equipped with mechanical stirrer and thermometer pocket at 25°C.2.Stir the mixture for 17 hours at 25°C.
3.Monitor the reaction by HPLC (starting material should be less than 4.0%).
4.Pour the reaction mixture on 3.0 kg of crushed ice, if HPLC complies.
5.Stir the mixture for 30 minutes and filter the solid material.
6.Wash the mixture with 1 L of water, suck dry and unload the material.
7.Dry the 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one under vacuum at 55-60°C till the LOD comes to below 0.5%.
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one запасные части и сырье
7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one поставщик
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