BENZO[E]PYRENE

Химические свойства

yellow to yellow-green crystalline powder

Физические свойства

Crystalline, solid, prisms, or plates. Benzo[e]pyrene is sensitive to ultraviolet light and may degrade into diones.

Использование

Used for studies of immune suppressive activity of bezo[e]Pyrene on antibody response to DNP-Ficoll and sheep erythrocytes and "dispersive liquid -liquid micro extraction” technique by extracting organic compounds from water samples.

Определение

ChEBI: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC.

Общее описание

Colorless crystals or white crystalline solid.

Реакции воздуха и воды

Insoluble in water.

Профиль реактивности

BENZO[E]PYRENE may be sensitive to prolonged exposure to light.

Угроза здоровью

There is very little information available onits toxicity. The oral toxicity is expected to below. Its carcinogenic potential is lower thanthat of benz[a]pyrene. Animal studies gaveinconclusive results. Oral administration mayproduce tumors in the stomach. However, theevidence of carcinogenicity of this compoundin animals is inadequate. Benz[e]pyrene isa mutagen, testing positive to the histidinereversion–Ames test and in vitro unscheduled DNA synthesis (UDS)–human fibroblast.

Пожароопасность

Flash point data for BENZO[E]PYRENE are not available. BENZO[E]PYRENE is probably combustible.

Профиль безопасности

For occupational chemicalanalysis use NIOSH: Polynuclear Aromatic Hydrocarbons(HPLC), 5506; (GC), 5515.

Экологическая судьба

Photolytic. Schwarz and Wasik (1976) reported a fluorescence quantum yield of ≈ 0.3 for benzo[e]pyrene in water.
Chemical/Physical. Benzo[e]pyrene will not hydrolyze because it has no hydrolyzable functional group.

Методы очистки

Purify it by passage through an Al2O3 column (Woelm, basic, activity I) and elute with *C6H6 and recrystallise from 2 volumes of EtOH/*C6H6 (4:1). It forms colourless or light yellow prisms or needles. [Campbell J Chem Soc 3659 1954, Buchta & Kr.ger Justus Liebigs Ann Chem 705 190 1967.] The 1,3,5-trinitrobenzene complex has m 253-254o (orange needles from EtOH), the picrate prepared by mixing 20mg in 1mL of *C6H6 with 20mg of picric acid in 2mL *C6H6, collecting the deep red crystals, and recrystallising from *C6H6 has m 228-229o [NMR: Cobb & Memory J Chem Phys 47 2020 1967]. [Beilstein 5 III 2520, 5 I V 2689.] CARCINOGEN.