Chromium picolinate

Химические свойства

Dark violet crystal

Использование

Chromium picolinate (CrPic), a dietay supplement, may be used to study its potential as a modulator of glucose uptake and the activity of insulin. CrPic is used to study its effects on nuclear factor-κ B (NF-κB) and nuclear factor-E2-related factor-2 (Nrf2) pathways in animals.

Общее описание

Chromium picolinate is a supplemental or alternative medication for type 2 diabetes and an anti-diabetic mechanisms of CrPic in insulin-resistant 3T3-L1 adipocytes.

Метаболизм

Chromium picolinate was found to be stable in rat stomach and small intestine contents in vitro, consistent with a previous study [110]. It was inferred that the complex disassociated at or near the intestinal wall, and the absorbed picolinic acid was excreted mainly as N-picolylglycine; however, ~8–10% of the radiolabel was excreted from the breath as CO2, plus an unidentified major metabolite was observed in mice along with N-picolylglycine[1]. Adipose, blood, and liver showed Cr levels 2–6 times higher than untreated animals, with the liver containing the highest amounts.