POLY(2-HYDROXYETHYL METHACRYLATE)

Использование

Poly(2-hydroxyethyl methacrylate) has been used:

• as a nonadhesive substrate in the preparation of single cell suspensions
• to implant into mice cornea for corneal micropocket assay
• to coat the well plates for sphere assay using adipose-derived mesenchymal stem cells

Определение

ChEBI: An acrylate macromolecule, composed of repeating 2-hydroxyethyl 2-methylpropanoate units.

Общее описание

Solid Poly(2-hydroxyethyl methacrylate) (pHEMA) is brittle, while pHEMA hydrogel is a soft material. Glass transition temperature for pHEMA hydrogels is reduced by increasing a content of water in the matrix. Macromolecular properties in pHEMA are characterized by non-covalent interactions of hydrogen-bonds among the polymer chains as well as the hydrated water molecules. The presence of polar groups of hydroxyl and carboxyl on each repeat unit makes this polymer compatible with water. The hydrophobic a-methyl groups of the backbone convey hydrolytic stability to the polymer and enhance mechanical strength of the polymer matrix.