ISOCORYDINE HYDROCHLORIDE
- русский язык имя
- английское имяISOCORYDINE HYDROCHLORIDE
- CAS №475-67-2
- CBNumberCB6238999
- ФормулаC20H23NO4
- мольный вес341.4
- номер MDLMFCD00075905
- файл Mol475-67-2.mol
химическое свойство
| Температура плавления | 216-220 °C(lit.) |
| альфа | D20 +195° (chloroform) |
| Температура кипения | 477.03°C (rough estimate) |
| плотность | 1.2064 (rough estimate) |
| показатель преломления | 1.5614 (estimate) |
| растворимость | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| форма | Cryst. |
| пка | 9.41±0.20(Predicted) |
| FDA UNII | 3B5E87JEOX |
| WGK Германия | 3 |
| RTECS | CE1057950 |
| Токсичность | LD50 intraperitoneal in mouse: 104mg/kg |
ISOCORYDINE HYDROCHLORIDE химические свойства, назначение, производство
Описание
Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.Использование
sedative, cholinergicиспользованная литература
See IsocorydineISOCORYDINE HYDROCHLORIDE запасные части и сырье
запасной предмет
ISOCORYDINE HYDROCHLORIDE поставщик
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