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Элокальцитол
- английское имяELOCALCITOL
- CAS №199798-84-0
- CBNumberCB61509111
- ФормулаC29H43FO2
- мольный вес442.65
- номер MDLMFCD09954119
- файл Mol199798-84-0.mol
химическое свойство
Температура кипения | 568.3±50.0 °C(Predicted) |
плотность | 1.05±0.1 g/cm3(Predicted) |
температура хранения | Store at -20°C |
растворимость | Ethanol:20.0(Max Conc. mg/mL);45.18(Max Conc. mM) |
форма | A crystalline solid |
пка | 14.04±0.40(Predicted) |
цвет | White to off-white |
оптическая активность | [α]/D +97 to +107°, c =c=1 in methanol |
FDA UNII | 2WDS5F2V6Q |
UNSPSC Code | 12352200 |
Элокальцитол химические свойства, назначение, производство
Описание
BXL-628 is an analog of vitamin D3 that has diverse biological activities. It increases death of androgen-stimulated human benign prostatic hyperplasia (BPH) cells via induction of apoptosis in a dose-dependent manner. In vivo, BXL-628 completely inhibits androgen-stimulated prostate overgrowth in a rat model of BPH. It reduces expression of IL-13 and IgE/mast cell-derived protease 1 (MMCP1) and decreases edema and leukocyte infiltration in the bladder wall in a mouse model of allergen-induced interstitial cystitis. BXL-628 also reduces the number of adherent endometrial stromal cells and decreases the total weight of endometrial lesions in a mouse model of endometriosis. Formulations containing BXL-628 are under clinical investigation for the treatment of BPH.Элокальцитол поставщик
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