1-ТРИФТОРМЕТИЛ-2,3,4,9-ТЕТРАГИДРО-1H-B-КАРБОЛИН
- английское имя1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
- CAS №112037-78-2
- CBNumberCB6140573
- ФормулаC12H11F3N2
- мольный вес240.22
- номер MDLMFCD00052089
- файл Mol112037-78-2.mol
химическое свойство
| Температура плавления | 147-149°C |
| Температура кипения | 350.0±37.0 °C(Predicted) |
| плотность | 1.351±0.06 g/cm3(Predicted) |
| пка | 16.63±0.40(Predicted) |
| Заявления о рисках | 36/37/38 |
| Заявления о безопасности | 26-36/37/39 |
1-ТРИФТОРМЕТИЛ-2,3,4,9-ТЕТРАГИДРО-1H-B-КАРБОЛИН химические свойства, назначение, производство
Механизм действия
Although βCCE and other β-carbolines are not endogenous BZR ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil) toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse agonist pharmacophores of the various GABAA/BZR subtypes.Клиническое использование
Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction procedure, has very high affinity for the BZR.