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Бензамидина гидрохлорид
- английское имяBenzamidine hydrochloride
- CAS №1670-14-0
- CBNumberCB6100733
- ФормулаC7H9ClN2
- мольный вес156.61
- EINECS216-795-4
- номер MDLMFCD00013025
- файл Mol1670-14-0.mol
химическое свойство
Температура плавления | 86-88 °C(lit.) |
температура хранения | 2-8°C |
растворимость | DMF: 25 mg/ml DMSO: 25 mg/ml Ethanol: 10 mg/ml PBS (pH 7.2): 3 mg/ml |
форма | Powder |
цвет | White to off-white |
РН | 4.0 to 6.5(50g/L, 25 ℃) |
Растворимость в воде | soluble |
БРН | 3594959 |
Стабильность | Stable for 2 years from date of purchase as supplied. Solutions are not stable and must be prepared fresh daily |
ИнЧИКей | LZCZIHQBSCVGRD-UHFFFAOYSA-N |
Справочник по базе данных CAS | 1670-14-0(CAS DataBase Reference) |
FDA UNII | 0G112W4L27 |
Система регистрации веществ EPA | Benzenecarboximidamide, monohydrochloride (1670-14-0) |
UNSPSC Code | 12352202 |
NACRES | NA.77 |
Коды опасности | Xi | |||||||||
Заявления о рисках | 36/37/38 | |||||||||
Заявления о безопасности | 26-37/39-36 | |||||||||
WGK Германия | 3 | |||||||||
RTECS | CV6260000 | |||||||||
F | 3-21 | |||||||||
кода HS | 29252900 | |||||||||
NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H315:При попадании на кожу вызывает раздражение.
H319:При попадании в глаза вызывает выраженное раздражение.
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оператор предупредительных мер
P264:После работы тщательно вымыть кожу.
P280:Использовать перчатки/ средства защиты глаз/ лица.
Бензамидина гидрохлорид химические свойства, назначение, производство
Описание
Benzamidine hydrochloride is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
Химические свойства
white to off-white powderИспользование
Benzamidine is a reversible inhibitor of serine proteases, including trypsin, plasmin, and thrombin (Kis = 35, 350, and 220 μM, respectively). In addition to its use as a general serine protease inhibitor, benzamidine is used, when immobilized, to purify novel proteases.Подготовка
To a stainless steel rocking autoclave equipped with a stirrer is added 103.0 gm (1.0 mole) of benzonitrile, 214.0 gm (4.0 mole) of ammonium chloride, and 306.0 gm (18.0 mole) of ammonia is introduced by means of a transfer bomb. The reaction mixture is heated at 150°C for 18 hr (pressure: 1300-6500 psig), cooled, and, with appropriate precautions for the safe control of the excess ammonia, is vented to atmospheric pressure. The reaction mixture is extracted with ether to remove approximately 5% unreacted benzonitrile, and then extracted with hot acetonitrile or ethanol to separate the amidine hydrochloride from the unreacted ammonium chloride. Concentration of the latter affords 120.5 gm (77%) of benzamidine hydrochloride, m.p. 161-163°C.
Биологическая активность
Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 μM, 21 μM, 20 μM and 110 μM for uPA, trypsin, tryptase and factor Xa, respectively.Профиль безопасности
Moderately toxic byintraperitoneal route. When heated to decomposition itemits toxic vapors of NOx, HCl, and Cl-.Бензамидина гидрохлорид запасные части и сырье
запасной предмет
- 2-ФЕНИЛ-4- [3H] ХИНАЗОЛИНОН
- Ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate
- 4-ХЛОРО-2-ФЕНИЛХИНАЗОЛИН
- 2-PHENYLPYRIMIDINE
- 4-ХЛОР-6-МЕТИЛ-2-ФЕНИЛ-ПИРИМИДИН
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