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![Флуметиазид структурированное изображение](/CAS/GIF/148-56-1.gif)
Флуметиазид
- английское имяflumethiazide
- CAS №148-56-1
- CBNumberCB5905531
- ФормулаC8H6F3N3O4S2
- мольный вес329.278
- EINECS205-717-4
- номер MDLMFCD01663210
- файл Mol148-56-1.mol
химическое свойство
Температура плавления | 306.6°C |
Температура кипения | 560.0±60.0 °C(Predicted) |
плотность | 1.6578 (estimate) |
пка | pKa 6.3(H2O) (Uncertain) |
Растворимость в воде | 1.05g/L(room temperature) |
FDA UNII | 3PA0CDS0M5 |
Банк данных об опасных веществах | 148-56-1(Hazardous Substances Data) |
Флуметиазид химические свойства, назначение, производство
Создатель
Ademol,Squibb,US,1959Производственный процесс
Chilled 3-trifluoromethylaniline (32.2 g) is added dropwise over a 45-minute period to 150 ml of chlorosulfonic acid with stirring and cooling. The ice bath is removed and 140 g of sodium chloride is added over 3 hours. The mixture is heated on a water bath for 30 minutes, then gradually up to 160°C over 6 hours. The cooled reaction mixture is diluted with 500 ml of an ice water slurry and taken into ether. The ether is dried and evaporated to leave 5- trifluoromethylamine-2,4-disulfonyl chloride.The crude residue is heated on the steam bath for 1 hour with 75 ml of concentrated ammonium hydroxide. Cooling and filtration gives 2,4- disulfamyl-5-trifluoromethylaniline, MP 241°C to 243°C.
This intermediate is treated with an excess of 98% formic acid at steam bath temperature for 3 hours. Evaporation and dilution with water gives 7-sulfamyl- 6-trifluoromethyl-1,2,4-benzothiadiazine-1,1-dioxide, MP 304°C to 308°C.
Терапевтическая функция
Carbonic anhydrase inhibitorФлуметиазид запасные части и сырье
Флуметиазид поставщик
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