АФЛАТОКСИН-B1
- английское имяAFLATOXIN B1
- CAS №1162-65-8
- CBNumberCB5389650
- ФормулаC17H12O6
- мольный вес312.27
- EINECS214-603-3
- номер MDLMFCD00869647
- файл Mol1162-65-8.mol
химическое свойство
| Температура плавления | 268-269 °C |
| альфа | D -558° (c = 0.1 in CHCl3); D -480° (c = 0.1 in DMF) |
| Температура кипения | 372.21°C (rough estimate) |
| плотность | 1.2810 (rough estimate) |
| показатель преломления | 1.4800 (estimate) |
| Fp | 2 °C |
| температура хранения | 2-8°C |
| растворимость | DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 12 mg/ml |
| форма | White to yellow powder. |
| цвет | White to yellow |
| Биологические источники | Aspergillus flavus |
| Растворимость в воде | 15mg/L(temperature not stated) |
| Мерк | 13,180 |
| БРН | 1269174 |
| Стабильность | Stable. Incompatible with strong oxidizing agents. May be light or air sensitive. |
| ИнЧИКей | OQIQSTLJSLGHID-WNWIJWBNSA-N |
| LogP | 2.039 (est) |
| FDA UNII | 9N2N2Y55MH |
| Система регистрации веществ EPA | Aflatoxin B1 (1162-65-8) |
| UNSPSC Code | 85151701 |
| NACRES | NA.77 |
больше
| Коды опасности | T+,T,Xn,F | |||||||||
| Заявления о рисках | 45-46-26/27/28-36-20/21/22-11-65-48/23/24/25-36/38-39/23/24/25-23/24/25 | |||||||||
| Заявления о безопасности | 53-45-36-26-16-24-7-62-36/37-28 | |||||||||
| РИДАДР | UN 3462 6.1/PG 1 | |||||||||
| WGK Германия | 3 | |||||||||
| RTECS | GY1925000 | |||||||||
| F | 10 | |||||||||
| Класс опасности | 6.1(a) | |||||||||
| Группа упаковки | I | |||||||||
| кода HS | 29322090 | |||||||||
| Банк данных об опасных веществах | 1162-65-8(Hazardous Substances Data) | |||||||||
| Токсичность | LD50 orally in day old duckling: 18.2 mg/50 gm body wt (Carnaghan); i.p. in newborn mice: 9.50 mg/kg body wt (Büchi) | |||||||||
| NFPA 704: |
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рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
опасность
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вредная бумага
H350：Может вызывать раковые заболевания.
H300+H310+H330：Смертельно при проглатывании, при контакте с кожей или при вдыхании.
H361：Предполагается, что данное вещество может отрицательно повлиять на способность к деторождению или на неродившегося ребенка.
H340：Может вызывать генетические дефекты.
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оператор предупредительных мер
P201：Беречь от тепла, горячих поверхностей, искр, открытого огня и других источников воспламенения. Не курить.
P262：Избегать попадания в глаза, на кожу или одежду.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P310+P330：ПРИ ПРОГЛАТЫВАНИИ: Немедленно обратиться за медицинской помощью. Прополоскать рот.
P302+P352+P310：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды. Немедленно обратиться за медицинской помощью.
P304+P340+P310：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Немедленно обратиться за медицинской помощью.
АФЛАТОКСИН-B1 химические свойства, назначение, производство
Химические свойства
The aflatoxins are a group of molds produced by the fungus Aspergillus flavus. They are natural contaminants of fruits, vegetables, and grains. They are also described as a series of condensed ring heterocyclic compounds. They form colorless to pale yellow crystals. Practically insoluble in water.Использование
Aflatoxin B1 is the major analogue of a family of bisfuranocoumarin mycotoxins produced by Aspergillus flavus and related species. Aflatoxin B1 exhibits a distinctive UV spectrum and blue fluorescence. Aflatoxins are among the most potent mycotoxins known but are in fact "pre-toxins", requiring metabolic activation to the toxic principle. Aflatoxins are found widely in nature in trace amounts, particularly in grains and nuts. The toxicity of these metabolites was first recognised in the 1950s and their structures elucidated in 1963. Aflatoxins have been extensively reviewed.Определение
ChEBI: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.Общее описание
Colorless to pale yellow crystals or white powder. Exhibits blue fluorescence.Реакции воздуха и воды
Sensitive to exposure to air and light. Water insoluble.Профиль реактивности
AFLATOXIN B1 is incompatible with strong oxidizing agents, strong acids and strong bases.Пожароопасность
Flash point data for AFLATOXIN B1 are not available; however, AFLATOXIN B1 is probably combustible.Профиль безопасности
Confirmed human carcinogen with experimental tumorigenic, neoplas tigenic, and carcinogenic data. Acute poison by ingestion, intraperitoneal, and possibly other routes. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke. See also various aflatoxins.Возможный контакт
Aflatoxins are a group of toxic metabolites produced by certain types of fungi. Aflatoxins are not commercially manufactured; they are naturally occurring contaminants that are formed by fungi on food during conditions of high temperatures and high humidity. Most human exposure to aflatoxins occurs through ingestion of contaminated food. The estimated amount of aflatoxins that Americans consume daily is estimated to be 0.15 0.50 μg. Grains, peanuts, tree nuts, and cottonseed meal are among the more common foods on which these fungi grow. Meat, eggs, milk, and other edible products from animals that consume aflatoxincontaminated feed may also contain aflatoxins. Aflatoxins can also be breathed inМетаболический путь
Aflatoxin B1 can be activated via the monooxygenase reaction which then reacts with the N7 atom of B-DNA guanine. Conjugation of aflatoxin B1 8,9-epoxide is an important detoxification route. Although aflatoxin B1 8,9-epoxide can be hydrolyzed to the diol by epoxide hydrolase, the diol product is toxic, since it reacts readily with proteins by Schiff base formation or binds to DNA. Glutathione conjugation prevents toxicity of both the epoxide and its hydrolysis product. The aflatoxin glutathione conjugate is subsequently excreted from the hepatocyte into bile as a major biliary metabolite.Перевозки
UN3172 Toxins, extracted from living sources, solid or liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.Несовместимости
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.Утилизация отходов
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Use of oxidizing agents, such as hydrogen peroxide or 5% sodium hypochlorite bleach. Acids and bases may also be used.АФЛАТОКСИН-B1 запасные части и сырье
АФЛАТОКСИН-B1 поставщик
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