27-ДЕОКСИАКТЕИН
- английское имя27-DEOXYACTEIN
- CAS №264624-38-6
- CBNumberCB5365803
- ФормулаC37H56O10
- мольный вес660.83
- номер MDLMFCD07783721
- файл Mol264624-38-6.mol
химическое свойство
| Температура плавления | 253～254℃ |
| плотность | 1.32±0.1 g/cm3(Predicted) |
| температура хранения | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| растворимость | Chloroform (Slightly), Methanol (Very Slightly), Pyridine (Slightly) |
| форма | Solid |
| пка | 13.03±0.70(Predicted) |
| цвет | White to Off-White |
| Стабильность | Hygroscopic |
| FDA UNII | 2D5AUV13AX |
27-ДЕОКСИАКТЕИН химические свойства, назначение, производство
Описание
23-epi-26-Deoxyactein is a triterpene glycoside and a major constituent of black cohosh (C. racemosa). It reduces intracellular calcium concentrations, collapse of the mitochondrial membrane potential, production of reactive oxygen species (ROS), and cardiolipin peroxidation and inhibits autophagy and apoptosis in osteoblastic MC3T3-E1 cells induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). 23-epi-26-Deoxyactein (0.01-10 μM) reduces production of ROS and IL-1β and cell death induced by methylglyoxal in RIN-m5F β-cells.Использование
27-Deoxyactein has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis. It is a derivative of Actein (A191800), a gamma secretase modulators derived from botanicals.27-ДЕОКСИАКТЕИН поставщик
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