Глицидол
- английское имяGlycidol
- CAS №556-52-5
- CBNumberCB5338946
- ФормулаC3H6O2
- мольный вес74.08
- EINECS209-128-3
- номер MDLMFCD00005147
- файл Mol556-52-5.mol
химическое свойство
| Температура плавления | -54 °C |
| Температура кипения | 61-62 °C/15 mmHg (lit.) |
| плотность | 1.117 g/mL at 25 °C (lit.) |
| плотность пара | 2.15 (vs air) |
| давление пара | 0.9 mm Hg ( 25 °C) |
| показатель преломления | n |
| Fp | 178 °F |
| температура хранения | -20°C |
| растворимость | Soluble in acetone, alcohol, benzene, chloroform, and ether (Weast, 1986) |
| пка | 14.62±0.10(Predicted) |
| форма | Powder, Crystals or Chunks |
| цвет | White to light yellow-beige |
| Растворимость в воде | soluble |
| Мерк | 13,4503 |
| БРН | 383562 |
| Пределы воздействия | TLV-TWA 75 mg/m3 (25 ppm) (ACGIH); 150 mg/m3 (50 ppm) (OSHA); IDLH 500 ppm (NIOSH). |
| Стабильность | Stability Stable, but may explode on contact with strong acids, strong bases, heavy metals, heavy metal salts. May decompose on exposure to water or moist air. |
| ИнЧИКей | CTKINSOISVBQLD-UHFFFAOYSA-N |
| LogP | -0.95 at 25℃ |
| Справочник по базе данных CAS | 556-52-5(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG | 6 |
| FDA UNII | S54CF1DV9A |
| Предложение 65 Список | Glycidol |
| Справочник по химии NIST | Glycidol(556-52-5) |
| МАИР | 2A (Vol. 77) 2000 |
| Система регистрации веществ EPA | Glycidol (556-52-5) |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
больше
| Коды опасности | T |
| Заявления о рисках | 45-60-21/22-23-36/37/38-68 |
| Заявления о безопасности | 53-45-36/37-26 |
| РИДАДР | UN 2810 6.1/PG 3 |
| OEB | A |
| OEL | TWA: 25 ppm (75 mg/m3) |
| WGK Германия | 3 |
| RTECS | UB4375000 |
| F | 10-21 |
| Температура самовоспламенения | 780 °F |
| Примечание об опасности | Toxic |
| Класс опасности | 6.1(b) |
| Группа упаковки | III |
| кода HS | 29109000 |
| Банк данных об опасных веществах | 556-52-5(Hazardous Substances Data) |
| Токсичность | Acute oral LD50 for mice 431 mg/kg, rats 420 mg/kg (quoted, RTECS, 1985). |
| ИДЛА | 150 ppm |
рисовальное письмо(GHS)
-
рисовальное письмо(GHS)
-
сигнальный язык
опасность
-
вредная бумага
H315：При попадании на кожу вызывает раздражение.
H319：При попадании в глаза вызывает выраженное раздражение.
H335：Может вызывать раздражение верхних дыхательных путей.
H341：Предполагается, что данное вещество вызывает генетические дефекты.
H350：Может вызывать раковые заболевания.
H330：Смертельно при вдыхании.
H360F：Может отрицательно повлиять на способность к деторождению.
H302+H312：Вредно при проглатывании или при попадании на кожу.
-
оператор предупредительных мер
P202：Перед использованием ознакомиться с инструкциями по технике безопасности.
P280：Использовать перчатки/ средства защиты глаз/ лица.
P301+P312：ПРИ ПРОГЛАТЫВАНИИ: Обратиться за медицинской помощью при плохом самочувствии.
P302+P352+P312：ПРИ ПОПАДАНИИ НА КОЖУ: Промыть большим количеством воды. Обратиться за медицинской помощью при плохом самочувствии.
P304+P340+P310：ПРИ ВДЫХАНИИ: Свежий воздух, покой. Немедленно обратиться за медицинской помощью.
P305+P351+P338：ПРИ ПОПАДАНИИ В ГЛАЗА: Осторожно промыть глаза водой в течение нескольких минут. Снять контактные линзы, если Вы ими пользуетесь и если это легко сделать. Продолжить промывание глаз.
Глицидол химические свойства, назначение, производство
Описание
Glycidol is a chiral molecule with epoxide and primary alcohol functional groups. It is racemic mixture and exists in the dextrorotatory and the levorotatory enantiomeric forms. Several synthetic methods are available for preparation of glycidol. However, it is commercially prepared from the epoxidation of allyl alcohol with hydrogen peroxide and a catalyst (tungsten or vanadium), or from the reaction of epichlorohydrin with caustic. Glycidol has been used in the industrial synthesis of pharmaceutical products since the 1970s. However, its use for research purposes has been reported since 1956. Available information indicates that glycidol is manufactured by several companies in Japan, Germany, and the United States.Химические свойства
Glycidol is a colorless liquid.Использование
Glycidol is a Stabilizer in the manufacture of vinyl polymers; chemical intermediate in preparation of glycerol, glycidyl ethers, esters, and amines; in pharmaceuticals; in sanitary chemicals.
Определение
an epoxideОбщее описание
Odorless clear colorless liquid.Реакции воздуха и воды
Sensitive to moisture.Профиль реактивности
Glycidol is sensitive to moisture. Glycidol is also sensitive to light. Glycidol may polymerize if heated above room temperature. Glycidol may darken on storage. Stability studies of Glycidol stored for two week protected from light indicated definite decomposition at 140° F, and strongly indicated instability at 77° F. A solution of Glycidol in water was found to be unstable when stored at room temperature, even after one day in the dark. Glycidol is incompatible with strong oxidizers. Glycidol will undergo explosive decomposition in the presence of strong acids or bases, salts (such as aluminum chloride, iron(III)chloride or tin(IV) chloride) or metals (such as copper and zinc). Glycidol is also incompatible with nitrates. Glycidol will attack some forms of plastics, rubber and coatings.Опасность
Toxic material. Probable carcinogen.Угроза здоровью
Glycidol is an eye, lung, and skin irri-tant. The pure compound caused severebut reversible corneal injury in rabbit eyes(ACGIH 1986). Exposure to its vapor causedirritation of lung in mice, resulting in pneu-monitis. There is no evidence of any cumula-tive toxicity. From the limited toxicity data,it appears that the health hazard to humansfrom its exposure is, primarily, respiratoryirritation, stimulation of the central nervoussystem, and depression.Glycidol is mutagenic, testing positive inthe histidine reversion–Ames test. There isno report of its carcinogenic action. Oraland intraperitoneal administration of gly-cidol in rats showed harmful effects onfertility.
Пожароопасность
Glycidol is combustible.Профиль безопасности
Confirmed carcinogen with carcinogenic data reported. Poison by intraperitoneal route. Moderately toxic by ingestion, inhalation, and sh contact. Experimental teratogenic and reproductive effects. A skin irritant. Human mutation data reported. Animal experiments suggest somewhat lower toxicity than for related epoxy compounds. Readdy absorbed through the skin. Causes nervous excitation followed by depression. Explodes when heated or in the presence of strong acids,bases, metals (e.g., copper, zinc), and metal salts (e.g., aluminum chloride, iron(II1) chloride, tin(Iy chloride). When heated to decomposition it emits acrid smoke and fumes. See also DIGLYCIDYL ETHER.Синтез
A method for directly preparing glycidol from glycerol is shown as following steps: putting a mixed solvent in a glass or enamel reaction kettle, adding glycerol to the mixed solvent, controlling the concentration of glycerol in the reaction liquid within the range of 0.5-3.0 mol/L, then adding a catalyst, and controlling the quantity of the catalyst to account for 0.01-0.20 of the weight of the glycerol; increasing the temperature of the mixed reaction liquid to the range of 40-100 ℃ under stirring condition and reacting at a constant temperature for 2-20 hours; and after reaction, filtering off the catalyst from the reaction liquid, then distilling the mixed reaction liquid, and collecting the fraction in the range of 160-161 ℃, thereby obtaining the product 2,3-glycidol.Возможный контакт
Glycidol is used as an intermediate in the synthesis of glycerol, glycidyl ethers, esters, and amines.Канцерогенность
Glycidol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.Экологическая судьба
Chemical/Physical. May hydrolyze in water forming glycerin (Lyman et al., 1982).Перевозки
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.Методы очистки
[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.Несовместимости
May form explosive mixture with air. Violent reaction with strong oxidizers, nitrates. Decomposes on contact (especially in the presence of heat) with strong acids, strong bases, water, metal salts, e.g., alu minum chloride, ferric chloride, and tin chloride), or metals (copper and zinc), causing fire and explosion hazard. Contact with barium, lithium, sodium, magnesium, and tita nium may cause polymerization. Attacks some plastics, rubber, and coatings.Утилизация отходов
Concentrated waste contain ing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.Глицидол запасные части и сырье
Глицидол поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия | |
|---|---|---|---|---|---|
| +86-023-6139-8061 +86-86-13650506873 |
China | 39894 | 58 | ||
| +8617531153977 | China | 5855 | 58 | ||
| +86-13131129325 | China | 5887 | 58 | ||
| +86-18400010335 +86-18034520335 |
China | 1015 | 58 | ||
| +8619933239880 | China | 861 | 58 | ||
| +86-18633929156 +86-18633929156 |
China | 972 | 58 | ||
| +86-18532138899 +86-18532138899 |
China | 939 | 58 | ||
| +86-16264648883 +86-16264648883 |
China | 3712 | 58 | ||
| +86-（0）57185586718 +86-13336195806 |
China | 29792 | 60 | ||
| +86-0371-55170693 +86-19937530512 |
China | 21632 | 55 |