3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
- русский язык имя
- английское имя3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
- CAS №1232410-49-9
- CBNumberCB52534719
- ФормулаC18H16N4O3S
- мольный вес368.41
- номер MDLMFCD19443686
- файл Mol1232410-49-9.mol
химическое свойство
| Температура плавления | 247-249°C |
| Температура кипения | 568.4±50.0 °C(Predicted) |
| плотность | 1.394 |
| температура хранения | -20°C |
| растворимость | Soluble in DMSO (40 mg/ml) |
| форма | powder |
| пка | 9.97±0.70(Predicted) |
| цвет | white to beige |
| Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| FDA UNII | BF884TQ935 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide химические свойства, назначение, производство
Описание
Ataxia-telangiectasia and Rad3-related protein (ATR) is a serine/threonine kinase that activates DNA processes related to the DNA damage response. VE-821 is an ATP-competitive inhibitor of ATR (IC50 = 26 nM). It augments DNA damage and cell death of cancer cells in response to radiation under normal and hypoxic conditions. VE-821 also sensitizes cancer cells to chemotherapy.Химические свойства
Bright Yellow SolidИспользование
VE 821 is a potent and selective inhibitor of DNA damage response kinase, ATR. VE 821 functions to disrupt DNA damage repair system of tumor cells, limiting their abilities for further growth.3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide поставщик
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