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Бефения гидроксинафтоат
- английское имяBEPHENIUM HYDROXYNAPHTHOATE
- CAS №3818-50-6
- CBNumberCB5206454
- ФормулаC28H29NO4
- мольный вес443.53
- EINECS223-306-8
- номер MDLMFCD00078960
- файл Mol3818-50-6.mol
химическое свойство
Температура плавления | 170-171° |
температура хранения | Store at -20°C |
растворимость | ≥ 20.85mg/mL in DMSO |
форма | Solid |
цвет | White to off-white |
FDA UNII | 47RU9546DX |
Код УВД | P02CX02 |
Бефения гидроксинафтоат химические свойства, назначение, производство
Использование
antibacterial, antilepretic, antituberculosisПоказания
This drug exhibits antihelmintic action by acting as a cholinergic agonist, causing paralysis of the parasite musculature. This facilitates its removal from the intestines. It is used for treating ascariasis, ankylostomiasis, enterobiasis, trichostrongyliasis, and tricocefalosis. A single dose of bephenium heals from 80 to 100% of patients infected with A. duodenale. It is less effective with respect to N. americanus. Synonyms of this drug are aclopar and others.Синтез
Bephenium, 3-hydroxy-2-naphthoat benzyldimethyl(2-phenoxyethyl) ammonia (38.1.37), is made by reacting the sodium salt of 3-hydroxy-2-naphthoic acid with benzyldimethyl(2-phenoxyethyl)ammonia chloride (38.1.36). This is in turn made from benzyl chloride and N-(2-phenoxyethyl)dimethylamine (38.1.35), which is synthesized by reacting sodium phenolate with 2-dimethylaminoethylchloride.Бефения гидроксинафтоат поставщик
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