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Betulinic acid
- русский язык имя
- английское имяBetulinic acid
- CAS №472-15-1
- CBNumberCB4667160
- ФормулаC30H48O3
- мольный вес456.71
- EINECS207-448-8
- номер MDLMFCD00009619
- файл Mol472-15-1.mol
химическое свойство
Температура плавления | 295-298 °C (dec.) (lit.) |
Температура кипения | 550.0±33.0 °C(Predicted) |
альфа | D25 +7.5° (c = 0.37 in pyridine) |
плотность | 1.065±0.06 g/cm3(Predicted) |
показатель преломления | 7.8 ° (C=0.9, Pyridine) |
температура хранения | 2-8°C |
растворимость | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
форма | Solid |
пка | 4.61±0.70(Predicted) |
цвет | White or off-white |
оптическая активность | [α]20/D +7.8°, c = 0.9 in pyridine |
Мерк | 14,1190 |
Стабильность | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
ИнЧИКей | QGJZLNKBHJESQX-FZFNOLFKSA-N |
LogP | 7.653 (est) |
Справочник по базе данных CAS | 472-15-1(CAS DataBase Reference) |
FDA UNII | 4G6A18707N |
Словарь наркотиков NCI | betulinic acid |
рисовальное письмо(GHS)
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рисовальное письмо(GHS)
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сигнальный язык
предупреждение
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вредная бумага
H413:Может вызвать долгосрочные отрицательные последствия для водных организмов.
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оператор предупредительных мер
P273:Избегать попадания в окружающую среду.
P501:Удалить содержимое/ контейнер на утвержденных станциях утилизации отходов.
Betulinic acid химические свойства, назначение, производство
Химические свойства
colorless NeedlesИспользование
Betulinic Acid is a natural pentacyclic triterpenoid. Betulinic Acid displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activati ng the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activityОпределение
ChEBI: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium cla iflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.Общее описание
Betulinic acid is a lupane-type triterpene, which can be prepared from betulin via oxidation using chromium oxide (VI). Along with anti-HIV-1 and anti-tumor activity, it also shows other bioactivities such as anti-inflammatory, antibacterial, in vitro antimalarial, anthelmintic and antioxidant activities.Биологическая активность
Natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF- κ B. Exhibits TRG5 agonist activity (EC 50 = 1.04 μ M).разработк И противоопухолевых препаратов
This compound is a pentacyclic triterpene obtained from Betula and Zizyphus species,which shows selective cytotoxicity against human melanoma cells (Shoeb2006). It generates reactive oxygen species, activates MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates the activity of aminopeptidase-N, and thereby inducesapoptosis in cancer cells (Desai et al. 2008; Fulda 2008).Betulinic acid запасные части и сырье
Betulinic acid поставщик
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