Собузоксан
- английское имяSobuzoxane
- CAS №98631-95-9
- CBNumberCB4498395
- ФормулаC22H34N4O10
- мольный вес514.53
- номер MDLMFCD00866498
- файл Mol98631-95-9.mol
химическое свойство
| Температура плавления | 128-130°; mp 132-133° (Cai, 1989) |
| Температура кипения | 664.9±55.0 °C(Predicted) |
| плотность | 1.272±0.06 g/cm3(Predicted) |
| растворимость | DMSO: 19 mg/mL |
| пка | 2.75±0.20(Predicted) |
| форма | solid |
| FDA UNII | R1308VH37P |
| WGK Германия | 2 |
| RTECS | FG1582500 |
| Токсичность | LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa) |
Собузоксан химические свойства, назначение, производство
Описание
Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.Использование
Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.Собузоксан поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
| +8618523575427 | China | 49732 | 58 | |
| +1-+1(833)-552-7181 | United States | 52924 | 58 | |
| 1-(800)-881-8210 | United States | 2123 | 70 | |
| 027-88041443 13072715837 |
China | 696 | 58 | |
| 0513-66337626 18051384581 |
China | 5127 | 58 | |
| -- | United States | 6075 | 58 |