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PF-04995274
- английское имяPF 04995274
- CAS №1331782-27-4
- CBNumberCB42668576
- ФормулаC23H32N2O6
- мольный вес432.51
- файл Mol1331782-27-4.mol
химическое свойство
температура хранения | Store at -20°C |
растворимость | DMSO:20.0(Max Conc. mg/mL);46.2(Max Conc. mM) |
форма | A crystalline solid |
цвет | White to off-white |
FDA UNII | XI179PG9LV |
PF-04995274 химические свойства, назначение, производство
Описание
PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay). It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg.PF-04995274 поставщик
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