PF-477736
- английское имяPF 477736
- CAS №952021-60-2
- CBNumberCB02535690
- ФормулаC22H25N7O2
- мольный вес419.49
- номер MDLMFCD16038847
- файл Mol952021-60-2.mol
химическое свойство
| плотность | 1.56 |
| температура хранения | 2-8°C |
| растворимость | DMSO: ≥20mg/mL |
| форма | powder |
| пка | 11.79±0.20(Predicted) |
| цвет | yellow |
| ИнЧИКей | NDEXUOWTGYUVGA-LJQANCHMSA-N |
| FDA UNII | XO23PGZ0SM |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
PF-477736 химические свойства, назначение, производство
Описание
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.Использование
P293850 is a selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage.Биохимия/физиол Действия
PF-477736 may be effectively used to resensitize platinum resistant ovarian cancer cells. PF-477736 alone or in combination with other chemotherapeutic agents may be used to treat triple-negative breast cancer.PF-477736 поставщик
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