SGI-1027
- русский язык имя
- английское имяSGI-1027
- CAS №1020149-73-8
- CBNumberCB42663344
- ФормулаC27H23N7O
- мольный вес461.52
- EINECS-0
- номер MDLMFCD27937047
- файл Mol1020149-73-8.mol
химическое свойство
| Температура плавления | >280℃ |
| плотность | 1.387±0.06 g/cm3(Predicted) |
| температура хранения | 2-8°C |
| растворимость | Soluble in DMSO (up to 35 mg/ml) |
| пка | 13.31±0.70(Predicted) |
| форма | powder |
| цвет | white to light brown |
| Стабильность | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SGI-1027 химические свойства, назначение, производство
Использование
SGI-1027 is a quinoline derivative and a potent inhibitor of DNA methyltransferase (DNMT). SGI-1027 can be used as a potential therapeutic agent for the treatment of cancer and other diseases and also as a research tool to investigate the role of DNMTs in epigenetic events.Биохимия/физиол Действия
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor with IC50 values of 6-13 μM for DNMT3B, DNMT3A and DNMT1. SGI-1027 directly inhibits DNMT activity by competing with the cofactor, S-adenosylmethionine (SAM) in the methylation reaction. SGI-1027 treatment of cancer cell lines induced degradation of DNMT1, but not DNMT3A or DNMT3B, and in RKO cells caused re-expression of the silenced tumor supressor genes p16, MLH1 and TIMP3.SGI-1027 запасные части и сырье
SGI-1027 поставщик
| поставщик | телефон | страна | номенклатура продукции | благоприятные условия |
|---|---|---|---|---|
| +undefined-21-51877795 | China | 32965 | 60 | |
| +1-781-999-5354 +1-00000000000 |
United States | 32161 | 58 | |
| +86-0371-86658258 +8613203830695 |
China | 30233 | 58 | |
| 86-571-88216897,88216896 13588875226 |
CHINA | 6312 | 58 | |
| +86-29-89586680 +86-15129568250 |
China | 22787 | 58 | |
| +1-2135480471 +1-2135480471 |
China | 10473 | 58 | |
| +1-708-310-1919 +1-13798911105 |
United States | 6391 | 58 | |
| +86-571-86626709 +86-18157142896 |
China | 9984 | 58 | |
| 13417589054 | China | 11681 | 58 | |
| +86-852-30606658 | China | 43340 | 58 |